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9:00
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Registration and coffee
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10:20
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Welcome and introduction
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Session 6: Vaccinology and Antivirals
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Chairs: Nicole Tischler and Maria Rosenthal
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10:30
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Invited speaker: Christian T. Happi, Redeemer's University, Nigeria / Harvard University, USA. Genomic Surveillance and Characterization of Microbial Threats Facilitates Early Detection and Containment of Disease Outbreaks in West Africa.
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11:00
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Deep Learning Affinity Maturation of Oropouche Virus Neutralizing Nanobodies.
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Shrestha Chakraborty, University of Cambridge, UK.
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Comprehensive Bunyavirus:Human Protein Interaction Mapping Identifies Shared Immune Evasion Strategies and Targets for Pan-Antiviral Therapeutics.
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Francisco J. Zapatero Belinchon, Gladstone Infectious Disease Institute, USA.
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Targeting the Promoter RNA Binding Sites within Lassa Virus L Protein.
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Gabriele Diana, Bernhard Nocht Institute for Tropical Medicine & Centre for Structural Systems Biology, Germany.
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Vaccination-induced human antibodies protect against Rift Valley fever in mice and marmosets.
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Paul Wichgers Schreur, Wageningen Bioveterinary Research, the Netherlands.
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Progressing an MVA-Hantavirus vaccine to clinical testing.
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Karen Buttigieg, UK Health Security Agency, UK.
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12:00
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Flash presentations Vaccinology and Antivirals (3 min each)
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Ribavirin prevents bunyavirus-induced nuclear disruption and alters the structure of viral replication organelles.
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Moisés García Serradilla, Universidad Complutense de Madrid, Spain.
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Validation of a Mopeia virus-based drug discovery pipeline suitable for antiviral research against mammarenaviruses.
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Martin Ferrié, KU Leuven, Belgium.
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Development of a Human Ex Vivo Alveolar Model Suitable For Mammarenavirus Biology Studies and Antiviral Research.
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Lotte De Haes, KU Leuven, Belgium.
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OrbiSIMS modelling and structural biology approaches reveal potential mechanisms of viral attenuation in recombinant arenaviruses.
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Alex Childs, University of Nottingham, UK.
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Rift Valley fever virus attenuation by codon deoptimization.
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Alejandro Brun, Centro de Investigación en Sanidad Animal (CISA), Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria, Consejo Superior de Investigaciones Científicas (INIA-CSIC).
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12:30
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LUNCH
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Session 2: Virus Entry and Assembly
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Chairs: Stephanie Monticelli and John Barr
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13:30
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Invited speaker: Amy Hartman, Center for Vaccine Research, Pittsburgh, USA. Host interactions and implications for tropism and disease.
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14:00
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Phosphatidylserine Receptors Mediate Entry of Crimean-Congo Hemorrhagic Fever Virus into Host Cells.
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Ezgi Kasikci, Albert Einstein College of Medicine, USA.
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Unravelling the functional impact of receptor usage on New World Arenavirus infection.
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Nayeli Aguilar Hernández, Friedrich-Loeffler-Institut, Germany.
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How do bunyaviruses pack it? A structural investigation of the ribonucleoprotein organisation of nairoviruses and phenuiviruses.
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Samantha Hover, University of Leeds, UK.
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The Rift Valley Fever Virus Envelope Assembles as an Unambiguous Jigsaw Puzzle.
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Jan Hellert, Centre for Structural Systems Biology, Germany.
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The Crimean-Congo hemorrhagic fever virus hijacks the liver lipid metabolic pathway for virion production.
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Solène Denolly, Centre International de Recherche en Infectiologie, University of Lyon, France.
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Autophagy and Lysosomal Dynamics During Oropouche virus Infection: Potential Mechanisms of Viral Egress.
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Kristel Gutierrez, University of São Paulo, Brazil.
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Cellular release and transfer of orthohantavirus nucleocapsid protein via a viral assembly-independent mechanism.
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Nicole D Tischler, Centro Ciencia & Vida, Fundación Ciencia & Vida, Chile.
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15:30
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Flash presentations Virus Entry and Assembly (3 min each)
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CCHFV uses phosphatidylserine receptors for cell entry via apoptotic mimicry.
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Janis A Müller, Philipps University Marburg, Marburg, Germany.
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Functional and structural insights into Bunyavirus glycoproteins under K+ treatment.
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Moisés Rojas Rechy, Instituto Biofisika, CSIC-UPV/EHU, Spain.
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Endosomal pathways as therapeutic targets for Oropouche Virus infection.
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Pierina Lorencini Parise, University of Campinas, Brazil.
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15:40
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Flash presentations Evolution, Epidemiology and Diagnostics (3 min each)
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Seroprevalence and associated risk factors of Rift Valley Fever in humans from three ecological zones of Senegal.
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Elisabeth Thérèse Faye, Institut Pasteur de Dakar Dakar, Senegal.
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Recombinant virology toolkit for Erve virus.
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Igor Starinskij, MRC-University of Glasgow Centre for Virus Research, UK.
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Performance Update on Rapid Diagnostic Test Kits for Detecting Lassa Fever in Nigeria.
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Faith Unuabonah, Ambrose Alli University, Ekpoma, Edo-state, Nigeria.
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Formulation of reference reagents for nucleic acid amplification testing for Toscana Virus.
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Daniel A Yara, Science and Research, Diagnostics, Medicines and Healthcare products Regulatory Agency, UK.
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Development of a Novel Antigen Detection System for Rapid and Accurate Diagnosis of Rift Valley Fever Virus.
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Mark Mawer, Liverpool School of Tropical Medicine, UK.
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16:00
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BREAK
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16:30
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Poster session 1: Evolution, Epidemiology and Diagnostics / Virus Entry and Assembly / Vaccinology and Antivirals
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18:30
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DINNER
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July 9th
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DAY 2
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Session 3: Virus replication
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Chairs: Natasha Tilston and Solene Denolly
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9:00
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Spatiotemporal Dissection of LCMV Infection Reveals Dynamic Viral Structures Essential for Virus Propagation.
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Kate Emily Gilroy, University of Leeds, UK.
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Characterization of Arenavirus Protein Phosphorylation and its Impact on the Viral Life Cycle.
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Marine-Noel Klamke, Institute of Molecular Virology and Cell Biology, Friedrich-Loeffler-Institut, Germany.
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Bunyaviruses Reprogram Host Translation via 5' TOP mRNAs.
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Karyme Paez, Albert Einstein College of Medicine, USA.
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Understanding the regulation of stress granules formation during bunyaviruses infection.
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Nicolas Locker, The Pirbright Institute, UK.
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Multi-omics analysis of host-virus interactions during Bunyaviricetes infection.
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Lara Rheinemann, Technical University of Munich, Germany.
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A Mosquito Cell-Based Rift Valley Fever Virus Minigenome System for Studying Viral Replication.
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Qilin Xin, University of York, UK.
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Structural and functional characterization of Rice Hoja Blanca virus RNA-dependent RNA polymerase.
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Itona Tarillon, Université Grenoble Alpes, France.
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10:30
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Flash presentations Virus replication (3 min)
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Developing a Split GFP System to Illuminate Nairovirus Trafficking and Replication.
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Sophia Qais, University of Leeds, UK.
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Molecular characterization of arenavirus defective viral genomes reveals sequence features associated with their formation.
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Thomas Hoenen, Friedrich-Loeffler-Institut, Germany.
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The mechanism of RNA synthesis inhibition by the Z protein in Lassa virus.
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Annika Rammelt, Bernhard Nocht Institute for Tropical Medicine & Centre for Structural Systems Biology, Germany.
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Rift Valley fever virus NSs drives genome wide changes in host mRNA splicing.
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Kiriaki Kouti, Justus-Liebig-University of Giessen, Germany.
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Identifying Determinants of Orthobunyavirus Reassortment.
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James M. Bowen, Indiana University School of Medicine, USA.
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The dynamics of OROV structural proteins during the viral replication cycle in HeLa cells.
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Igor Valencio Medeiros, University of São Paulo, Brazil.
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11:00
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COFFEE BREAK
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Session 4: Antiviral Immunity and Pathogenesis
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Chairs: Toshana Foster and Maria Rosenthal
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11:30
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Towards the mechanistic basis of GP38-triggered vascular leak during Crimean-Congo hemorrhagic fever virus infection.
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Stephanie Monticelli, U. S. Army Medical Research Institute of Infectious Diseases, USA.
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Orthobunyavirus-host interactions determine susceptibility to neuroinvasive disease.
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Alyssa Evans, Montana State University, USA.
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Antibody breadth against diverse hantaviruses emerges following Puumala virus infection.
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Jordan Clark, Icahn School of Medicine at Mount Sinai, USA.
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Non-neutralizing Functions of Anti-LASV IgGs in Lassa Fever Survivors from Edo State, Nigeria.
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Solvej Oberhof, Bernhard Nocht Institute for Tropical Medicine, Germany.
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Impacts of Oropouche virus infection of trophoblast cells on host and viral microRNA regulation.
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Juliano Souza, University of São Paulo, Brazil.
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Visualisation of RVFV-Induced Cellular Remodelling and NSs Filaments.
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Märit-Runa Jönsson, Centre for Structural Systems Biology, Germany.
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The antiviral response of skin-associated muscle to La Crosse virus infection is age-dependent.
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Emily Kirby, Rocky Mountain Laboratories, NIAID, NIH, USA.
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13:00
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Flash presentations Antiviral Immunity and Pathogenesis (3 min each)
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Host responses in human Lassa Fever patients.
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Lisa Oestereich, Bernhard Nocht Institute for Tropical Medicine, Germany.
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Development of a Single-Domain Antibody-Fc Therapeutic for Broad Protection Against Lassa Virus.
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Taylor Powell, U. S. Army Medical Research Institute of Infectious Diseases, USA.
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Oropouche Virus-induced Congenital Disease and Its Prevention by 4′-Fluorouridine.
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Maïlis Darmuzey, Rocky Mountain Laboratories, NIAID, NIH, USA.
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Vector saliva reprograms dermal fibroblasts to create a permissive niche for Bunyaviruses infections.
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Yonca Keskek Turk, University of Leeds, UK.
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The anti-apoptotic Rift Valley fever virus NSm protein interferes with Bax pro-apoptotic protein.
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Charlotte Romanet, Institut Pasteur, France.
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Comparative study of experimental infection by Oropouche virus lacking nonstructural proteins NSm or NSs in mice.
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Eurico Aruda, University of São Paulo, Brazil.
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13:30
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LUNCH
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14:30
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Poster session 2: Virus replication / Antiviral Immunity and Pathogenesis
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16:15
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Group picture
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16:30
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Walk to Guggenheim
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17:00
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Guided tours Guggenheim museum
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20:00
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GALA DINNER
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July 10th
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DAY 3
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Session 5: Vector Biology
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Chair: Benjamin Brennan
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9:00
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Segment-specific virus-derived DNA biogenesis regulates Batai virus replication in Aedes albopictus.
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Marléne Cavaleiro Pinto, Swedish University of Agricultural Sciences, Sweden.
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Genomic determinants of La Crosse virus vector competence in the primary vector Aedes triseriatus.
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Briana Marsico, Colorado State University, USA.
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Decoding the Hyalomma anatolicum proteome to understand Orthonairovirus cross-species adaptation.
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Harry Taylor, University of Surrey, UK.
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Synthesis of vDNA forms upon acute and persistent Tahyna virus infection in mosquito cells.
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Davide Sogliani, Istituto Zooprofilattico Sperimentale della Lombardia e dell’Emilia-Romagna, Italy.
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9:50
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COFFEE BREAK + Poster session 3 (extra time for posters)
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Session 1: Evolution, Epidemiology and Diagnostics
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Chairs: Juan Fontana and Lisa Oestereich
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11:00
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Invited speaker: Elisabeth Fichet-Calvet, BNITM, Germany. The complex ecology of Lassa virus in West Africa.
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11:30
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Talks of 12 min each (10 min presentation + 2 min for questions)
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Genetic divergence in fetal Schmallenberg virus isolates compromises vector competence.
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Kerstin Wernike, Friedrich-Loeffler-Institut, Federal Research Institute for Animal Health, Germany.
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Genetic and Phenotypic Changes of Multi-host Viruses LaCrosse and Jamestown Canyon Virus After Adaption to A Single Host.
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Kishana Taylor, Towson University, USA.
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Investigating the Role of Temperature in Reassortment Potential of Orthobunyaviruses in Insect Cells.
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Samm Clark, Louisiana State University School of Veterinary Medicine, USA.
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Protein-based tools for the detection and characterisation of Oropouche virus infection.
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Stephen Graham, University of Cambridge, UK.
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A Rapid, Point-of-Care Diagnostic Test for Crimean-Congo Haemorrhagic Fever.
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Rachel Owen, Liverpool School of Tropical Medicine, Liverpool, UK.
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12:30
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Poster prizes
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12:45
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Closing remarks
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13:00
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FINISH
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